Controlled release of encapsulated methylene blue in a multilayered textile coating

Adeline Martin,Nicolas Blanchemain,Laurent Leclercq,Feng Chai,Bernard Martel,Nicolas Tabary,François Aubert-Viard,Jatupol Junthip

doi:10.1051/matecconf/20130704012

Abstract

We studied the formation of multilayered coating incorporating a β-cyclodextrin polyelectrolyte onto a pretreated polyethylene terephthalate (PET) textile in order to obtain reservoir and sustained release properties towards bioactive molecules. This paper describes the alternate deposition by dip-coating onto the textile of chitosan (CHT) and a β-cyclodextrin polyelectrolyte (polyCTR- βCD) according to the layer-by-layer (LbL) principle. Textiles covered with up to 12 layers were characterized by gravimetry, infrared, zetametry. The building of the multilayer system was then achieved including methylene blue (MB) as bioactive model compound, complexed with polyCTR-βCD, and a release study of BM was investigated in batch. The results showed that the release profile of BM could be controlled by the number of layers in the system.

Highlights

In the last two decades, surface treatments of biomaterials have been investigated aiming to modify their physicochemical properties to control cell proliferation or adhesion, or to create drug delivery system (GarcıaGonzalez et al 2011)
The aim of the present study is to build an innovative system of a multilayer assembly on a pretreated polyethylene terephthalate (PET) using the LbL process, using a polymer of βcyclodextrin as a polyanion with an active molecule encapsulated in the cavities, and chitosan as a polycation, a biosourced biocompatible polymer
Optical Waveguide Lightmode Spectroscopy (OWLS), zetametry and gravimetry confirmed that chitosan and poly-βCD were alternatively deposited on the surface

Summary

SUMMARY

We studied the formation of multilayered coating incorporating a β-cyclodextrin polyelectrolyte onto a pretreated polyethylene terephthalate (PET) textile in order to obtain reservoir and sustained release properties towards bioactive molecules. This paper describes the alternate deposition by dip-coating onto the textile of chitosan (CHT) and a β-cyclodextrin polyelectrolyte (polyCTRβCD) according to the layer-by-layer (LbL) principle. Textiles covered with up to 12 layers were characterized by gravimetry, infrared, zetametry. The building of the multilayer system was achieved including methylene blue (MB) as bioactive model compound, complexed with polyCTR-βCD, and a release study of BM was investigated in batch. The results showed that the release profile of BM could be controlled by the number of layers in the system

INTRODUCTION

RESULTS AND DISCUSSION

CONCLUSION