Abstract
Copolymers of 2-hydroxyethyl methacrylate (HEMA) and methacrylic acid (MAA) based hydrogels containing 5 and 10% of a cross-linking agent were studied as drug delivery systems. Terephthalic acid was covalently linked with HEMA, abbreviated as CA. Radiation copolymerization of HEMA and MAA, mixed with a particulate glibenclamide with the various ratios CA as crosslinking agent were carried out at the room temperature. The structure of the CA was confirmed by FTIR, 1H NMR and 13C NMR spectroscopy. The compositions of the cross-linked three-dimensional polymers were determined by FTIR spectroscopy. Glass transition temperature (Tg) of the network polymers was determined calorimetrically. The hydrolysis of drug-polymer conjugates was carried out in cellophane membrane dialysis bags containing an aqueous buffer solution (pH 7.4 and pH 1) at 37°C. The drug-release profiles indicate that amount drug release depends on their degree of swelling and cross-linking.
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