Abstract
The feasibility of producing controlled release indomethacin microspheres, with acrylic polymers Eudragit RS and RL, by employing two emulsion solvent-diffusion systems, is compared. Microspheres with various polymer/drug ratios and polymer combinations (Eudragit RS/RL ratios) were prepared. The physical properties, loading efficiency and dissolution behaviour depended on the emulsion solvent-diffusion technique, polymer/drug ratio and polymer combination. The drug release is described on the basis of two bi-exponential, first-order models.
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