Abstract
Acidic proteinoid and basic proteinoid were included in the water channel of the cubic phase to design a pH-sensitive monoolein (MO) cubic phase. Proteinoid composed of Asp and Leu (PAL) and proteinoid of Lys (PL) were prepared by a melt-condensation method and they used as acidic and basic porteinoid, respectively. Maximum complexation between PAL and PL was observed at pH 7.0 and at the PAL/PL ratio of 3/7 (v/v), evidenced by the size and the light scattering intensity of PAL/PL complexes. Fluoresceinisothiocyanate-dextran (FITC-dextran) release from cubic phase containing PAL/PL (3/7, v/v) was relatively high under an acidic and an alkali condition but the release was significantly suppressed under a neutral condition (e.g., pH 7.0), where maximum complexation was observed. The complex formed in the water channel of the cubic phase is believed to control the release in response to a change in the pH of release medium.
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