Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery.

Thao T D Tran,Phuong H L Tran

doi:10.3390/pharmaceutics11060290

Abstract

Despite many available approaches for transdermal drug delivery, patient compliance and drug targeting at the desired concentration are still concerns for effective therapies. Precise and efficient film-forming systems provide great potential for controlling drug delivery through the skin with the combined advantages of films and hydrogels. The associated disadvantages of both systems (films and hydrogels) will be overcome in film-forming systems. Different strategies have been designed to control drug release through the skin, including changes to film-forming polymers, plasticizers, additives or even model drugs in formulations. In the current review, we aim to discuss the recent advances in film-forming systems to provide the principles and review the methods of these systems as applied to controlled drug release. Advances in the design of film-forming systems open a new generation of these systems.

Highlights

The development of controlled drug delivery systems has generated substantial interest in pharmaceutical science in recent years [1,2,3]
The hydrogel structure has poor resistance to wearing and washing due to its hydrophilicity, it has been reported in a sustained release form [22,23]
This study indicated that an film-forming systems (FFSs) containing nonivamid loaded on silica particles sustained drug delivery and had advantages of not using irritating emulsifiers in the FFS compared to two previous studies [56,57,58]

Summary

Introduction

The development of controlled drug delivery systems has generated substantial interest in pharmaceutical science in recent years [1,2,3]. Transdermal drug delivery has attracted researchers with multiple approaches because multiple dosing or insufficient drug delivery often results in low therapeutic effects [4,5,6,7,8] Among these techniques, films (patches) and gels have been extensively designed for use in skin diseases or wound care in the past decades [9,10,11,12,13,14,15,16,17]. Films (patches) and gels have been extensively designed for use in skin diseases or wound care in the past decades [9,10,11,12,13,14,15,16,17] These dosage forms can contain drugs for therapeutic applications. The hydrogel structure has poor resistance to wearing and washing due to its hydrophilicity, it has been reported in a sustained release form [22,23]

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Conclusion