Abstract
Alzheimer’s disease is the most prevalent cause of dementia in aging people. 7-Methoxytacrine (7-MEOTA) is one of the approved drugs for the treatment of this disease. In the current study, a 7-MEOTA delivery system was prepared based on the polycaprolactone nanocapsules (7-MEOTA@PCL), and its physico-chemical properties were investigated. The drug amount loaded in nanocapsules has been estimated 65%. The average particle size of the 7-MEOTA@PCL nanocapsules was around 237 nm with a polydispersity index of 0.31 and negative surface charge (− 21.2 mV). The prepared nanoparticles are stable upon 40 days of storage at 25 °C, without any decomposition. The morphological analysis of the 7-MEOTA@PCL nanoparticles indicated that the nanoparticles are spherical and free of any aggregation. In vitro release experiments revealed the controlled release of the 7-MEOTA from the polycaprolactone nanocapsules. Application of the Korsmeyer–Peppas model to the release kinetics data showed that the release of the drug was by diffusion Fick’s law.
Highlights
Drug delivery is one of the most important and complex branches of pharmacology which has significantly expanded today with the aid of other scientific fields
A 7-MEOTA delivery system has been prepared based on the polycaprolactone nanocapsules (7-MEOTA@PCL) and its physico-chemical properties were investigated as well
The controlled drug release is the process through which a carrier such as polymeric, metal, protein or lipid nanoparticles is purposefully combined with the active drug to release it in the body in a predetermined and desired manner
Summary
Drug delivery is one of the most important and complex branches of pharmacology which has significantly expanded today with the aid of other scientific fields. A system with continuous drug release must be biodegradable and biocompatible in order to be able to release a therapeutic agent into the body, and increase the degree of effectiveness and safety of the drug through controlling the rate, time and place of release This system is used to transfer and store an appropriate amount of drug for a period of time. As one of the best DDSs, the polymeric nanoparticles have been extensively explored in recent years [16,17,18,19,20] These substances are able to carry a wide range of drugs to the specific parts of the body within certain period of time. Given the experience of the present research group related to the use of PCL nanocapsules in the pharmaceutical and agricultural industries [41,42,43], in the present study, it has been attempted to load 7-MEOTA drug on PCL nanoparticles as a useful release system and investigate its physico-chemical properties using various analytical techniques
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