Controlled ovarian hyperstimulation (COH) with sequential hpfsh & hmg versus rec-F.S.H alone in ICSI cycle

Abstract

Background: In spite of there are several publications on COH protocols evaluating the efficacy of various exogenous gonadotropins, no established protocols exist, and it isn’t very clear which is best to the others. Aims and objectives: The aim of this work is to investigate the sequential use of hpFSH+hHMG vs. rFSH alone on fertility outcome (rate of gestation, abortions and live delivery) in ICSI-cases. Subjects and methods: This work recruited patients referred for assisted reproduction treatment (ART) cycles to Global Nile Infertility Center. Under supervised of main principal investigator during the period from February, 2020 to February, 2021 according to study protocol. Result; Clinical pregnancy ratios were 71% . in Group 1,54% in Group-2. Group-1 was detected to have elevated clinical gestation ratios in comparison with other group, more over there was statistical significance0.01. Conclusion: Hp-HMG adding can be utilized as a choice for correcting of outcomes in those whose respond is unpredictably suboptimal to ovulation inductions with HP-FSH throughout GnRH agonist protocols. The elevated yield of oocyte with r-FSH doesn’t lead to high embryos quality. Hp-HMG supplement is a choice to improve IVF outcomes in patient's ovulation inductions with HP-FSH throughout GnRH agonist down-regulations. Mainly, hp-HMG is suggested as it can have an advantageous action on implantations on the particular group but to prone the effectiveness extensive prospective randomized control trials must be performed.