Abstract
Design of polymeric micelles, formed by self-assembly of amphiphilic block copolymers, is crucial for encapsulation of poorly soluble drugs, leading to the development of promising carrier systems. Herein, we synthesized amphiphilic diblock copolymers of 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) and methacrylate R-polyhedral oligomeric silsesquioxanes (POSS) (vertex R-groups of POSS cage modified with ethyl (C2H5), hexayl (C6H13), octayl (C8H17) alkyl chain) via RAFT polymerization technique. Polymeric micelle was formed in aqueous environment, and the absolute size was calculated to be around 26–43 nm. The increased alkyl chain length of the R-groups of POSS led to loosely packed association of the micelles. The polymeric micelles encapsulated the hydrophobic model drugs (paclitaxel and α-tocopherol), and the encapsulation efficiency was strongly dependent on the structure of drug molecules. The drug-loaded micelles were stable for 5 days at 25 °C. The release % of both the drugs from the micelles...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
