Abstract
SUMMARY The anthelmintic activity of morantel has been demonstrated in controlled laboratory trials involving natural and experimental infections in sheep. Single oral doses of 6 mg./kg. and higher of a 2 per cent aqueous solution of the tartrate salt resulted in high activity against Haemonchus, Ostertagia, Trichostrongylus, Nematodirus, Cooperia, Oesophagostomum and Chabertia. Activity against Trichuris and Dictyocaulus was low or absent. Immature stages of abomasal and small intestinal worms were also highly susceptible to the drug. The safety margin is approximately twenty times the therapeutic dose of 10 mg./kg.
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