Abstract
Jean-Marc Chavatte and Georges Snounou discuss research involving controlled malaria infections.
Highlights
In a recent report in PLOS Medicine, Rebecca Watts and colleagues followed this tradition by describing controlled human infection (CHI) with artemisinin-resistant Plasmodium falciparum [2]
CHIs became so important for malaria studies that when malariotherapy was superseded by antibiotics, malariologists initiated ethically sanctioned volunteer programs
Allan Saul and his team at the Queensland Institute of Medical Research (QIMR) broke this moratorium by bringing together 3 elements needed to embark on CHI initiated by blood stage malaria parasites
Summary
In a recent report in PLOS Medicine, Rebecca Watts and colleagues followed this tradition by describing controlled human infection (CHI) with artemisinin-resistant Plasmodium falciparum [2]. CHIs became so important for malaria studies that when malariotherapy was superseded by antibiotics, malariologists initiated ethically sanctioned volunteer programs.
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