Controlled growth of metal-organic frameworks on small intestinal submucosa for wound repair through combined antibacterial and angiogenic effects

Abstract

Regenerating infectious wound tissues resulting from bacterial invasion is an ongoing challenge. In this study, a novel wound dressing with both antibacterial and angiogenic capacities is developed to combat refractory infection and promote wound repair. The system (termed SIS/ZIF) is fabricated through a one-pot synthesis of zinc-containing zeolitic imidazolate framework (i.e., ZIF-8) on the surface of small intestinal submucosa (SIS). By optimizing the preparation period, the SIS/ZIF demonstrated excellent sustained release rates of Zn2+ up to 14 days, antibacterial efficiency (＞96 %) and accelerated vascularization (2.17-fold greater than commercial wound dressings). Furthermore, transcriptome analysis suggested that the SIS/ZIF dressing achieved tissue repair via activating the hypoxia-induced factor-α pathway. In a rat model of wound injuries with bacterial intervention, the SIS/ZIF showed robust potentials to eradicate bacteria and promote tissue regeneration. We believe this versatile material would be promisingly applicable to wound healing.