Controlled Drug Release from Biodegradable Bone Fillers

Abstract

Plaster of Pairs is a common used implanting material. However, its rapid degradation or drug releasing rate as a bone filler or drug carrier does not meet the requirement of clinic application. In this paper, plaster of Pairs bone fillers loaded with drug was prepared and their degradation and the drug release period were adjusted by coating their surface with polymers. The results show that the structure of coatings can effectively control the degradation period of the bone fillers, and consequently the drug release rate.