Controlled drug release contenders comprising starch/poly(allylamine hydrochloride) biodegradable composite films

Abstract

The blending of natural polysaccharides with synthetic polymers has attracted much attention in drug delivery models owing to their remarkable biodegradable and biocompatible characteristics. This study focuses on the facile preparation of a sequence of composite films having Starch/Poly(allylamine hydrochloride) (ST/PAH) in different compositions to propose a novel drug delivery system (DDS). ST/PAH blend films were developed and characterized. FT-IR evaluation confirmed the involvement of intermolecular H-bonding between the ST and PAH counterparts in blended films. The water contact angle (WCA) ranged from 71° to 100° indicating that all the films were hydrophobic. TPH-1 (90 % ST and 10 % PAH) was evaluated for in vitro controlled drug release (CDR) at 37 ± 0.5 °C in a time-dependent fashion. CDR was recorded in phosphate buffer saline (PBS) and simulated gastric fluid (SGF). In the case of SGF (pH 1.2), the percentile drug release (DR) for TPH-1 was approximately 91 % in 110 min, while the maximum DR was 95 % in 80 min in PBS (pH 7.4) solution. Our results demonstrate that the fabricated biocompatible blend films can be a promising candidate for a sustained-release DDS for oral drug administration, tissue engineering, wound dressings, and other biomedical applications.