Abstract
Sustained release systems were made by incorporating 5-fluorouracil (5-FU) in an ethylene-vinyl alcohol copolymer. When exposed to aqueous medium, the delivery systems released the drug slowly and continuously. Upon exposure to ultrasound, the drug was released at a much higher rate. Release rates returned to base line levels when the ultrasound irradiation was discontinued. This study demonstrated that release rates of 5-FU from polymers can be increased at desired times by external ultrasound irradiation.
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