Controlled drug delivery vehicles for cancer treatment and their performance

Sudipta Senapati,Sunil Kumar,Pralay Maiti,Arun Kumar Mahanta

doi:10.1038/s41392-017-0004-3

Sudipta Senapati, Sunil Kumar + Show 2 more

Open Access

https://doi.org/10.1038/s41392-017-0004-3

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Abstract

Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

Highlights

Cancer includes a range of diseases that arise as a result of the unregulated growth of malignant cells, which have the potential to invade or spread to other body parts
The drug delivery platform based on mechanized silica nanoparticles (MSNPs), which consists of Mesoporous silica nanoparticles (MSN) vehicles, acid-cleavage intermediate linkages and reversible supramolecular nanovalves, was devised to achieve multimodal controlled release of two drugs, gemcitabine (GEM) and doxorubicin (DOX), by arranging the order of stimuli in sequence
Magnetic carriers for drug delivery using superparamagnetic nickel ferrite nanoparticles functionalized with poly(vinyl alcohol), poly(ethylene oxide) and poly(methacrylic acid) (PMAA) and subsequently conjugated with doxorubicin anticancer drug have significantly enhanced the release rate under magnetic fields by creating mechanical deformation, which generates compressive and tensile stresses to eject drug molecules[162]

Summary

Introduction

Cancer includes a range of diseases that arise as a result of the unregulated growth of malignant cells, which have the potential to invade or spread to other body parts. Multifunctional Taxol-loaded PLGA nanoparticles magnetic albumin microspheres in the targeted delivery of an show chemotherapeutic and near-infrared photothermal destrucanticancer agent compared to the pure drug in rat model is tion of cancer cells in vitro and in vivo[69].

Results

Conclusion