Abstract
A composite nanoresonant structure is developed for sensitivity enhancement in biorecognition reactions by coupling between the localized resonance and the propagating surface plasmon polariton waves. The resonant structure was accomplished by combining holographic lithography with an oblique metallic deposition for cost-effective, large-area, and reconfigurable fabrication. The metallodielectric nanostructure was assembled with microfluidic channels and examined for biorecognition reactions, which showed pronounced improvement in the limit of detection compared to conventional nanohole array sensing configurations. The temperature influence on the binding affinity and the effectiveness of the control channel were also investigated to demonstrate the capability of the proposed composite nanoresonant surface plasmon resonance array sensor.
Highlights
Since the discovery of extraordinary transmission through subwavelength nanohole arrays [1], nanohole array have been used in surface plasmon resonance (SPR) sensors as an alternative to the prism-based Kretschmann–Raether configuration [2,3] and the diffraction grating approach [4]
In order to improve the limit of detection by increasing the sensitivity of the nanohole array based sensor, the coupling between the localized surface plasmon resonances (LSPRs) and propagating surface plasmon polaritons (SPPs) was investigated [13], and its potential to further increase sensitivity was proposed [14]
We present a composite mushroom-like metallodielectric nanostructure (MMN) as an alternative approach to couple these two types of plasmonic phenomena and exploit them for practical applications such as biorecognition reactions
Summary
Since the discovery of extraordinary transmission through subwavelength nanohole arrays [1], nanohole array have been used in surface plasmon resonance (SPR) sensors as an alternative to the prism-based Kretschmann–Raether configuration [2,3] and the diffraction grating approach [4]. Alternative approaches utilize nanoparticle-based SPR, whose sensitivity depends on the near-field amplitude of the electric fields that are created by the excited localized surface plasmon resonances (LSPRs) used to detect the binding effects [9,10,11,12]. In order to improve the limit of detection by increasing the sensitivity of the nanohole array based sensor, the coupling between the LSPRs and propagating surface plasmon polaritons (SPPs) was investigated [13], and its potential to further increase sensitivity was proposed [14]. The improved sensing technique would be susceptible to the background, making it impossible to accurately identify the biorecognition reaction in low concentrations
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