Abstract
In this report, an ocular device for the controlled delivery of pilocarpine was evaluated in albino rabbits using miosis as a bioassay for efficacy. The device was fabricated using Gelfoam® (absorbable gelatin sponge, USP) in the form of a matrix system. The efficacy of the device was compared in a cross-over study to the two conventional ophthalmic pilocarpine dosage forms, the eyedrop and the gel. The in-vivo results show that the gelfoam device is more effective than the two conventional pilocarpine dosage forms in prolonging the duration of the pilocarpine activity.
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