Abstract
Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a metal–organic framework (MOF) nanoplates to reduce the degradation rate of AZ91 magnesium alloy. Zeolitic imidazolate frameworks (ZIF-8) with a specific surface area of 1789 m2 g−1 were prepared by solvothermal methods, and after dispersion in a chitosan solution (10% w/w), the suspension was electrospun on the surface of AZ91 alloy. Studying the degradation rate in simulated body fluid (SBF) by electrochemical analysis including potentiodynamic polarization and electrochemical impedance spectroscopy reveals that the degradation rate of the surface-modified implants decreases by ~ 80% as compared with the unmodified specimens. The reduced alkalization of the physiological environment and hydrogen release due to the implant degradation are shown. In vitro studies by fibroblasts and MG63 osteosarcoma cells exhibit improved cell adhesion and viability. The mechanisms behind the improved degradation resistance and enhanced bioactivity are presented and discussed. Surface modification of MBIs by MOF-chitosan coatings is a promising strategy to control the biodegradation of magnesium implants for bone regeneration.
Highlights
Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone
We studied the effect of the metal–organic framework (MOF)/chitosan composite films on the biodegradation rate by the Tafel polarization test and electrochemical impedance spectroscopy (EIS)
To control the biodegradation rate of AZ91 magnesium alloy in physiological environments, composite films of ZIF-8 MOF/chitosan were deposited on the surface by electrospinning
Summary
Magnesium-based implants (MBIs) have recently attracted great attention in bone regeneration due to elastic modulus similar to bone. Surface modification of MBIs by MOF-chitosan coatings is a promising strategy to control the biodegradation of magnesium implants for bone regeneration. Albite all the aforementioned advantages of MBIs, the low corrosion resistance of magnesium alloys in physiological environments (PE) results in a rapid loss of mechanical integrity and growth of hydrogen bubbles that severely impair the bone healing process[8]. Different studies have shown that surface modification by depositing a coating layer improves biocompatibility, and encourages bone ingrowth, osseointegration induction, and mesenchymal stem cell p roliferation[17,18]. Heakal and Bakry[22] employed spin-coating to deposit a thin chitosan film on AXJ530 alloy They showed that the biodegradation rate of the magnesium alloy in PBS was significantly retarded. BG particles enhance bioactivity, cell adhesion, and cell proliferation
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