Meeting abstracts from the 64th British Thyroid Association Annual Meeting

C. N. Hales ,Bridget Knight ,Illaria Muller,Mohd Draman Yusof,Graham Leese ,Rashim Salota,Owain Leng,Ameen Bakhsh,Stephen Hyer ,Lewis E. Braverman ,Ahmed Al‐Sharefi ,Shiao Chan,Elizabeth N. Pearce ,Marian Ludgate,John Watkinson ,Alice Fletcher,Neil V. Morgan,Colin Dayan,Kirsten McEwan,Kate Langley,Carla Moran,Beverley M. Shields,Thomas Mcdonnell,Onyebuchi Okosieme,Jon Hoffman,John Welbourn Gregory ,Dt Bishop ,Eamonn R. Maher,Luigi Bartalena,Alasdair Coles,Sarah Healy,Jayne A. Franklyn ,Emma R. Woodward,Xuemei He,Rachel Sturley,John Lazarus,Mohd Shazli Draman ,Krishna Chatterjee,Nicola Hellen,Rebecca Thompson,Hannah Nieto,Lei Zhang,Nikhil Johri,Joanne Jones,Yvonne Wallis,Barbara Torlińska ,Peter Taylor,Anita Thapar,Ilaria Muller,Enrique Soto-Pedre,Neil Robertson,Nadia Pariani,Sue Channon,Michael Gyedu,Mark Willis,Christopher Campbell,Christopher Mccabe ,Luke Marsh,Neil Sharma,Su Ann Tee ,Arron Lacey,Arshiya Tabasum,N. Wake ,Taha Nasser,Alvin E. Rodin ,Andrew Turnell ,Kaixin Zhou,Vikki L. Poole,Joel Smith ,Waraporn Imruetaicharoenchoke,Martin Read ,Kristien Boelaert,Bijay Vaidya,Vicki Smith ,Aled Rees,Alex Rees,Cheong Ooi ,Daniel Thayer,Eric Fliers,Scott M. Nelson ,Jim Fong ,Jamie J. Coleman ,Bhavika Modasia,Robert A. James

doi:10.1186/s13044-016-0036-8

Abstract

Meeting abstracts from the 64th British Thyroid Association Annual Meeting

Highlights

Suboptimal thyroid function in pregnancy is associated with adverse obstetric outcomes but it is unclear whether levothyroxine treatment, initiated during pregnancy is beneficial
In the present study we investigated the association of PTTG and pituitary tumor-transforming gene-binding factor (PBF) with p53-related genes in the TCGA thyroid cancer dataset, as well as in a bi-transgenic murine model (Bi-Tg) overexpressing PTTG and PBF in the thyroid gland
Characterisation of primary murine Bi-Tg thyrocytes revealed that coexpression of PTTG and PBF caused extensive repression of DNA-damage repair (DDR) genes (39/82 genes; P < 0.05)

Summary

Introduction

Suboptimal thyroid function in pregnancy is associated with adverse obstetric outcomes but it is unclear whether levothyroxine treatment, initiated during pregnancy is beneficial. Results In MCF-7 and MDA-MB-231 breast cancer cells with either exogenous or all-trans retinoic acid/dexamethasone-induced NIS expression, PBF significantly repressed radioiodine uptake and this was reversible with PP1 treatment. Conclusions TRAb is commonly used regionally with good sensitivity and specificity We propose that it should be added on by biochemistry labs in all newly thyrotoxic patients, as this could expedite diagnosis, minimising use of inappropriate antithyroid medications. The thyroxine absorption test is an established test to investigate the cause of persistently raised TSH in patients on levothyroxine. Method Patients with persistently raised TSH despite adequate thyroxine dose and admitting good compliance were offered the test. They were advised to fast and bring their own medication.

Objectives

Methods

Results