Abstract
This work aimed to prepare solvent-free or green Bi2O2CO3 for quantum dot nanostructures (QDNSs) based on cellulose as a stabilizer and green capping agent to sorafenib delivery for liver targeting. Because the walnut tree is one of the most abundant trees in Iran, it was tried to synthesize Bi2O2CO3 QDNSs using a walnut skin extract. The saturation magnetization for Bi2O2CO3 QDNSs was calculated to be 68.1. Also, the size of products was measured at around 60–80 nm with the Debye–Scherrer equation. Moreover, the morphology, functional groups, and crystallography of the Bi2O2CO3 nanoparticles were investigated using atomic force microscopy, scanning electron microscopy, vibrating-sample magnetometer, and Uv–vis spectroscopy. The results demonstrated that Bi2O2CO3 QDNSs have opto-magnetic properties and they can be suggested as the candidate materials for the sorafenib delivery on the liver tissue. The optical band gap estimated for Bi2O2CO3 QDNSs was found to be red-shift from 3.22 eV. This study suggests the preparation of the Bi2O2CO3 QDNSs based on cellulose as new opto-magnetic materials at different temperatures of 180 °C, 200 °C, 220 °C, and 240 °C for sorafenib delivery as a type of biological therapy drug.
Highlights
In the past three d ecades[1,2,3], nanotechnology has seen significant advances in nanomaterials and new methods and materials
The synthesized products were characterized by X-ray diffraction (XRD), energy dispersive spectroscopy (EDX), Atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and UV–vis spectroscopy
To investigate the crystallographic properties and crystalline phases, the products were measured with X-ray diffraction (XRD) throughout the manufacturing process
Summary
In the past three d ecades[1,2,3], nanotechnology has seen significant advances in nanomaterials and new methods and materials. Magnetic and optic B i2O2CO3 NPs-based delivery systems provide a good-looking method for localizing sorafenib as clinically important oral tyrosine kinase drugs in the liver using magnetic forces and optical effects. These drugs act at relatively long-range and do not affect most biological tissues. There are different physical and chemical methods for the synthesis of nanostructures in medicine such as chemical remediation15,16, lithography[17], the ultrasonic method[18], co-precipitation[19], and microwave method[20] The disadvantages of this method are the use of chemicals that act as restorative and stabilizing a gents[21]. The synthesized products were characterized by X-ray diffraction (XRD), energy dispersive spectroscopy (EDX), Atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and UV–vis spectroscopy
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