Abstract
Present work is aimed at preparing hybrid composites based on graphene oxide and hydroxyapatite as a matrix (GO/HA), which can be used as a template for drug delivery after chirurgical operation. Composite materials were synthesized through an in situ precipitation as simple and save-time method. The obtained materials were characterized using infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and X-ray diffraction (XRD). Hybrid materials were loaded with amoxicillin and the drug delivery during various periods of time was assessed with UV spectroscopy. During loading periods, it was noted that GO has a much larger cumulative drug concentration compared to hydroxyapatite and other composites. Similarly, and during the release process, amoxicillin is released much faster during the earlier stage of immersion before reaching a stationary state towards long periods of time. This variation was found to be dependent on the amount of GO in the HA matrix, as well as on the number of oxygen available on the GO sheets and the HA surfaces.
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