Controllable Micro/nano Biofabrication of Fascinating Composites based on Bacterial Cellulose

Abstract

Event Abstract Back to Event Controllable Micro/nano Biofabrication of Fascinating Composites based on Bacterial Cellulose Guang Yang1 1 Huazhong University of Science & Technology, Department of Biomedical Engineering, College of Life Science & Technology, China Microorganisms in nature have rich variety, whose sizes are from nano to microscale. Therefore, microbes can be used as natural building blocks in nano/micro multilevel fabrication processes. Based on the urgent need of micro/nano biological manufacture of microorganism, four controlling methods: molecular template, magnetic control, microfluidics, and bio-printing for biological manufacture process suitable for microbe have been proposed to dip into the moving mode of microorganism and design new micro/nano functional materials by controlling directed movement and ordered arrangement of microorganism living cells. It could be really creative attempts in the microbial field. Bacterial cellulose (BC) is secreted by microorganism. Its biocompatibility, mechanical strength, chemical and morphologic controllability make it a natural choice for adoption in biomedical fields, including use as biomaterial for wound dressing, artificial blood vessels, vascular grafts, scaffolds for tissue engineering and controlled-release drug carriers. More than that, BC is a natural hydrogel, its high water content can carry other monomeric, reactive and potentially polymerizable species into BC’s inner network, essentially occupying the void volume and interacting with chain segments or pendant moieties of the BC. Therefore, Varity of composites based BC were synthesized and expand the application of BC. BC composites are primarily synthesized through in situ addition of reinforcement materials to BC synthetic media or the ex situ penetration of such materials into BC microfibrils. In our group’s research, Micropatterned BC can be guided neuronal growth, tubular BC can be used as artificial blood vessel. BC combine with biomacromolecules such as chitosan, hyaluronic acid, Au-DAPT nanoparticles, collagen, silk fibroin and so on, can be used in wound dressing and cosmetic. BC combine with Poly(NIPAM-co-BMA), which has thermoresponsive property, suitable for vascular embolization interventional therapy. BC combine with carbon nanotubes or conductive polymers, which has electractive property, can be used as flexible supercapacitor, electrodes, and have potential to be used to build a biology–device interface to produce implantable biosensors, electrostimulated drug release devices, and implantable devices for personalized and regenerative medicine. This work was supported by the National Natural Science Foundation of PR China (21574050, 31270150)