Controllable Drug Release Behavior of Polylactic Acid (PLA) Surgical Suture Coating with Ciprofloxacin (CPFX)-Polycaprolactone (PCL)/Polyglycolide (PGA).

Shuqiang Liu,Man Zhang,Jie Zhang,Fu Li,Juanjuan Yu,Yao Zhang,Huimin Li,Mingfang Liu,Jie Wu,Gaihong Wu,Bowen Wang,Kaiwen Wang,Peng Wang,Yifan Jing

doi:10.3390/polym12020288

Abstract

Polylactic acid (PLA) surgical suture can be absorbed by human body. In order to avoid surgical site infections (SSIs), the drug is usually loaded on the PLA suture, and then the drug can release directly to the wound. Because the different types of wounds heal at different times, it is needed to control the drug release rate of PLA suture to consistent to the wound healing time. Two biopolymers, polyglycolide (PGA) and polycaprolactone (PCL), were selected as the carrier of ciprofloxacin (CPFX) drug, and then the CPFX-PCL/PGA was coated on the PLA suture. The degradation rate of drug-carrier can be controlled by adjusting the proportion of PCL/PGA, which can regulate the rate of CPFX drug release from PLA suture. The results show that the surface of PLA suture, coating with PCL/PGA, was very rough, which led to increased stitching resistance when we were suturing the wound. These materials, such as the PLA suture, the PCL/PGA carriers and the CPFX drug, were just physically mixed rather than chemically reacted, which was very useful for ensuring the original efficacy of CPFX drug. With the increasing of PCL in the carriers, both the breaking strength and elongation of these un-degraded sutures increased. During degradation, the breaking strength of all sutures gradually decreased, and the more PCL in the coating materials, the longer effective strength-time for the suture. With the increasing of PCL in the drug-carrier, the rate of drug releasing became lower. The drug release mechanism of CPFX-PCL/PGA was a synergistic effect of drug diffusion and PCL/PGA carrier dissolution.

Highlights

Polylactic acid (PLA) polymer has some good properties, such as biocompatibility, biodegradability, non-toxicity and high strength, so it is usually used as the biomedical and pharmaceutical material [1,2,3].PLA has a good compatibility with human tissues, and can be gradually degraded into safe products of CO2 and H2 O in vivo
The filaments, which are made of PLA, can be used as the suture which can be absorbed bysurgical human suture body [4,5,6]
The drug carrier was made from PGA ((C4 H4 O4 )n, Mw = 11,602 g/mol) and PCL ((C6 H10 O2 )n, Mw = 50,000 g/mol), which were supplied by Natureworks Company (Blair, NE, USA)

Summary

Introduction

Polylactic acid (PLA) polymer has some good properties, such as biocompatibility, biodegradability, non-toxicity and high strength, so it is usually used as the biomedical and pharmaceutical material [1,2,3]. PLA has a good compatibility with human tissues, and can be gradually degraded into safe products of CO2 and H2 O in vivo. The intermediate product of PLA is lactic acid (LA), which is the normal sugar metabolite and does not accumulate in human’s vital organs. The filaments, which are made of PLA, can be used as the suture which can be absorbed by human body [4,5,6]. The filaments, which are made of PLA, can be used as the suture which can be absorbed bysurgical human suture body [4,5,6]

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Conclusion