Control parameters of the blood-pressure regulatory system. 2. Open-loop gain, reference pressure and basal heartrate.

Abstract

The open-loop gainG0 reference pressureP0 and basal heartrateR0 of the blood-pressure regulatory system have been estimated under four different experimental conditions by employing an aortic balloon and assuming a theoretical approach based on a 1st-order linear model. Mean values of 1·7–3·7, 75–130 mmHg, and 95–130 beats/min were obtained forG0,P0 andR0, respectively. Significant variations in these parameters were observed when the anaesthetic conditions were changed. It is suggested thatG0,P0 andR0 may have useful clinical applications both in characterising hypotensive and hypertensive syndromes and also in assessing the effect of anaesthetic agents.