Abstract
RATIONALE: For house dust mite control, most of the presently used acaricides are based on benzyl benzoate. This and other synthetics are under critical observation due to side effects. As an alternative, formulations based on neem (margosa) oil are available as OTC products in Europe. Seven of these products have been tested for their effect on house dust mites. METHODS: Following the ISO guide line, ANFOR NFG39-011, the neem oil derived products were tested for their effect against a mixed culture of D. farinae mites/eggs for 14 weeks. RESULTS: Starting with 200 mites and 50 eggs each, control reached an average level of 3.550 mites after 14 weeks. All the neem oil containing preparations showed no acaricidal effect. There was a clear difference in their inhibitory activity, however. Only two of them, TN-MP100® and Milbiol®, were able to inhibit growth and reproduction down to an insignificant level of about 100 mites after 14 weeks. All the other five products also significantly reduced growth and reproduction of the house dust mite, but only in the range of two thousand to 500 mites. CONCLUSIONS: TN-MP100® and Milbiol® are highly effective and safe neem formulations for the control of the house dust mite and consequently of house dust allergy. The results clearly demonstrate the high effect of the two neem based products against the allergens producing house dust mite.
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