Abstract
Hybrid materials obtained by sol-gel process are able to degrade and release Si compounds that are useful in regenerative medicine due to their osteoinductive properties. The present work studies the behavior of new organic-inorganic sol-gel coatings based on triple mixtures of alkoxysilanes in different molar ratios. The precursors employed are methyl-trimethoxysilane (MTMOS), 3-glycidoxypropyl-trimethoxysilane (GPTMS) and tetraethyl-orthosilicate (TEOS). After optimization of the synthesis conditions, the coatings were characterized using 29Si nuclear magnetic resonance (29Si-MNR), Fourier transform infrared spectrometry (FT-IR), contact angle measurements, hydrolytic degradation assays, electrochemical impedance spectroscopy (EIS) and mechanical profilometry. The degradation and EIS results show that by controlling the amount of TEOS precursor in the coating it is possible to tune its degradation by hydrolysis, while keeping properties such as wettability at their optimum values for biomaterials application. The corrosion properties of the new coatings were also evaluated when applied to stainless steel substrate. The coatings showed an improvement of the anticorrosive properties of the steel which is important to protect the metal implants at the early stages of the regeneration process.
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