Control of social status by sex steroids: insights from teleost fishes

Abstract

Many animals live in highly social environments, in which individuals must behave in a way that enables them to survive and live harmoniously among conspecifics. Dominance hierarchies are typical among social species and are essential for determining and preserving stability within social groups. Although there is considerable evidence that sex steroid hormones regulate behaviors associated with dominance, such as aggression and mating, fewer studies have examined the role of these hormones in controlling social status, especially in species that exhibit social hierarchies. Furthermore, despite this research, we know remarkably little about the precise neural and molecular mechanisms through which sex steroids modulate traits associated with social rank. Here, we review the neuroendocrine regulation of social status by sex steroids in teleost fishes, the largest and most diverse vertebrate group that shows extensive variation in reproductive systems and social structures between species. First, we describe the function of sex steroids and novel steroid-related genes that teleost fishes possess due to a lineage-specific whole-genome duplication event. Then, we discuss correlational, pharmacological, and molecular genetic studies on the control of social status by sex steroids in teleost fishes, including recent studies that have implemented gene editing technologies, such as CRISPR/Cas9. Finally, we argue that gene editing approaches in teleost studies, within both integrative and comparative frameworks, will be vital for elucidating the role of sex steroids in controlling social rank and characterizing their neural and molecular mechanisms of action. Collectively, ongoing and future research in these species will provide novel insight into the evolution of the regulation of social status by sex steroids and other neuroendocrine substrates across vertebrates.