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Abstract
CONTENTS –Sex determination in the fruit fly and nematode–Somatic sex determination – Dosage compensation – Germ‐line sex determination–Mammalian sex determination signifies testis determination – The mammalian sex‐determining master‐regulatory gene, SRY–XX and XY sex reversal in man – Sex‐determining region Y chromosome (SRY) –Is SRY the primary testis determinant?– Biochemical properties of SRY – Sequence versus structure recognition – SRY: positive or negative regulation?– Evidence for other mammalian sex‐determining genes–Murine autosomal sex‐determining genes – Wilms' tumour gene WT1 –Chromosomal abnormalities associated with sex reversal – Müllerian inhibiting substance: a target of SRY?–Perspectives
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