Abstract
ABSTRACTSchizophrenia is characterized by an adverse clinical course and poor psychosocial functioning, and causes problems in the social-cognitive sphere. Clozapine is a potent antipsychotic agent...
Highlights
Schizophrenia is a psychiatric disorder which may disrupt functionality of both patients and their caregivers, and it may be refractory despite treatment with multiple antipsychotic therapies
Atonic seizures should be considered in patients who have drop attacks during clozapine therapy and atonic seizures should be treated by using an anticonvulsant agent such as valproic acid/sodium valproate when it is inappropriate to reduce clozapine dose
We presented atonic seizures following clozapine therapy, which was recovered with addition of valproic acid/sodium valproate in a female patient with schizophrenia
Summary
Schizophrenia is a psychiatric disorder which may disrupt functionality of both patients and their caregivers, and it may be refractory despite treatment with multiple antipsychotic therapies. Atonic seizures should be considered in patients who have drop attacks during clozapine therapy and atonic seizures should be treated by using an anticonvulsant agent such as valproic acid/sodium valproate when it is inappropriate to reduce clozapine dose.
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