Abstract
THE HIV-l PROMOTER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 718 Distal Enhancer Sequences . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 718 T Cell Activation Signals and NF-KlJ .. .. . .. ........ ...... . . . . . 721 The Basal Promoter: Spl, TATA, and the Initiator. . . . . . . . . . . . . . . . . . . 722 Downstream Elements: LBP-l, 1ST, and TAR . . . . . . . . . . . . . .. . . . . . . . 723 TRANSCRIPTION ACTIVATION BY TAT THROUGH TAR ... ...... ... . 724 Domain Structure of Tat .. . ......... . ........ 724 Structure of TAR RNA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 727 Recognition of Tat by TAR in vivo and in vitro . . . . . . . . . . . . . . . . . . . . . 730 Binding of Cellular Factors to TAR RNA . . . . . . . . . . . . . . . . . . . . . . . . . 731 Cellular Factors that Interact with Tat 733 Mechanism of Trans-activation by Tat . . . . . . . . . . . . . . . . . . . . . . . . . . . 734
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