Control of Rhythm and Rate278Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis279Exploration of the dominant-negative effect of a SCN5A mutation in mice using adeno-associated viruses280Modeling susceptibility to drug-induced long qt syndrome with a panel of subject-specific induced pluripotent stem cells

Maarten De Smet ,Jens Hansen ,Chi-Wing Kong ,Francesca Stillitano ,N Wang ,Noël Zahr ,Alain Coulombe ,Luc Leybaert ,Alessio Lissoni ,Pascale Guicheney ,Michel Clergue ,R Li ,Dorota Jeziorowska ,Ravi Iyengar ,Nathalie Mougenot ,Nathalie Neyroud ,Hajjar Rj ,Nicolas Doisne ,Christian Funck‐Brentano ,Marta Grauso ,J S Hulot

doi:10.1093/cvr/cvw140

Control of Rhythm and Rate278Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis279Exploration of the dominant-negative effect of a SCN5A mutation in mice using adeno-associated viruses280Modeling susceptibility to drug-induced long qt syndrome with a panel of subject-specific induced pluripotent stem cells

Maarten De Smet , Jens Hansen + Show 19 more

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https://doi.org/10.1093/cvr/cvw140

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Publication Date: Jul 1, 2016

Affiliation: Icahn School of Medicine at Mount Sinai, Cardiovascular Research Center, Ghent University, Institute of Cardiometabolism And Nutrition, Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris

#Drug-induced QT #Elevation Of Cytoplasmic Ca2 + Show 8 more

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Abstract

Control of Rhythm and Rate278Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis279Exploration of the dominant-negative effect of a SCN5A mutation in mice using adeno-associated viruses280Modeling susceptibility to drug-induced long qt syndrome with a panel of subject-specific induced pluripotent stem cells

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