Abstract

34 speakers participated in a workshop on the control of male fertility and the information they presented is summarized in this report. Possible targets for contraceptive action include: 1) the anterior pelvic ganglia with its adrenergic neurons 2) interference with a sperm-coating protein 3) use of small molecular weight compounds in the permeable epididymis and 4) enzyme inhibitors which affect sperm motility. Vasectomy is discussed including the relative lack of success in achieving pregnancy (30%) after successful restoration of the vas. The use of reversible valves and other occluding devices also has problems in restoring normal sperm count. Use of chemical methods of vas occlusion has a higher failure rate than that of standard vasectomy. No adverse effects of vasectomy on the endocrinological status of the patients have been detected. Data on antibody development in vasectomized men suggest there is large variability (20%-50%) in the number who develop sperm-immobilizing and sperm-agglutinating activity.

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