Abstract
This hypothesis proposes: (1) that small lymphocytes carry a recognition site on their surface; (2) that detection of lymphocytes carrying this recognition site (possibly during migration across the endothelium of the post-capillary venule) inhibits lymphocyte proliferation, thus maintaining normal numbers of lymphocytes; (3) that the recognition site is identical with the phytohæmagglutinin-responsive site and is closely associated with sites reacting with specific antigens; and (4) that the recognition site is lost or blocked in chronic lymphocytic leukæmia and in some of the lymphomas.
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