Abstract
The activity of low K m cAMP-phosphodiesterase (PDE) was determined in extracts of prostate and heart of adult (10–12 months old) and aged (32–35 months old) Sprague—Dawley rats; the enzyme's response to endogenous inhibitors extracted from the two organs was analyzed by kinetic studies. Different mechanisms of inhibition, non-competitive in prostate and competitive in heart extracts, indicate organ-specificity of the inhibitor. The decreased PDE activity in organ extracts of aged rats and its continued sensitivity to the endogenous inhibitor suggest an age-associated impairment of the tissues' ability to terminate cAMP-mediated signals.
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