Abstract
It is experimentally known that the viscosities of aqueous solutions are the dominant source of friction in the dynamics of lipidic pores in large vesicles. Building on an existing model of others in which membrane viscosity is assumed to limit pore dynamics, a new theory is developed that also accounts for aqueous viscosity. The equations that describe pore dynamics leads to a three-stage pattern, as in the prior theory, but the parameters of the new theory agree with experiments. The dissipation of energy resulting from friction between a membrane sliding against the aqueous solution, during changes in pore radius, is derived from fundamental principles of fluid mechanics, and the derived curve fits experimental data without the need to introduce fitting parameters.
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