Abstract
The DNA sequence of 306 base-pairs preceding and within the first structural gene of the leu operon of Escherichia coli, leuA, was determined. A prominent feature of this sequence is a signal for transcription termination. In vitro, transcription does terminate at this site, yielding a leader RNA of about 165 nucleotides. This leader RNA is potentially translatable into a peptide containing 28 amino acids, four of which are adjacent Leu residues. Several regions of base complementarity exist within the leader RNA. When the nucleotide sequences of the leu leaders of E. coli and Salmonella typhimurium are compared these segments are conserved while other segments vary appreciably. The highly conserved regions are those thought to play a functional role in attentuation control of leu operon expression.
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