Abstract
Using a murine model of Klebsiella pneumoniae bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.
Highlights
Neonatal infections, including pneumonia and sepsis, remain a significant cause of mortality and morbidity, with an estimated 3 million neonatal deaths occurring every year worldwide [1]
As a consequence of this, well-resourced settings have implemented therapeutic drug monitoring of GEN serum levels to reduce the incidence of toxicity [4]
In outpatient resource-poor settings, this regimen has challenges and many neonates do not receive appropriate treatment [10]. For those that do receive antibiotics, drug levels are unmonitored and first-line care is often provided by those lacking specialist pediatric training, often resulting in dose miscalculations and subsequent toxicity
Summary
Donnellya aSchool of Pharmacy, Medical Biology Centre, Queens University Belfast, Belfast, United Kingdom bWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast, Belfast, United Kingdom
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