Abstract
Investigation of a possible hormonal control of intrinsic factor secretion associated with vitamin B12 deficiency was done using parabiotic rat experiments. Although total intrinsic factor secretion per hour from the stomachs of these vitamin B12 deficient animals was not significantly increased over control values; the tendency toward increased secretion, as well as increased secretion when measured by concentration, suggests that there may be a blood-borne substance released from the stomachs of B12 deficient rats which increases intrinsic factor release from the normal rat stomach. The possible existence of a previously undescribed gastric hormone which regulates intrinsic factor secretion without affecting gastric juice volume and acid secretion is discussed.
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