Abstract

Enormous changes have been brought about in society by the reduction of morbidity and mortality caused by infectious diseases. The nature of the change is borne in upon people from prosperous countries when they visit countries in the Third World and witness the impact of sporadic infections or of epidemics of infection caused by organisms long forgotten elsewhere. Readers of the diary of Samuel Pepys are struck by the frequency of the sudden death of relatively prosperous middle-aged people of his acquaintance in seventeenth century London caused by infections of various sorts, even in non-plague years. Pepys’ account of the Great Plague of London in 1665, or Defoe’s Journal of the Plague Year, are incomparable testimony to the transformation which has taken place.

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