Abstract
community has followed the period of excitement created by the identification of members of the chemokine receptor family as essential co-receptors for the en- try of HIV into CD4+T cells. This in- formation has now been absorbed and is prompting new insights into HIV pathogenesis and potential for new treatment. One key area of research has been to examine how expression of the principal co- receptors [CCR5 for macrophage- tropic (M-tropic), non-syncytium- inducing (NSI) virus; CXCR4 for T cell line-tropic, syncytium-inducing (SI) strains] might be regulated. At first, studies were limited to mRNA expression, but the use of an emerging armoury of specific mono- clonal antibodies, in combination with other T-cell markers, has
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