Control of evaporative heat loss during changes in plasma osmolality in the cat.

Abstract

1. The effects of intravenous infusion of hypertonic saline and distilled water into normally hydrated and dehydrated cats have been examined at both high and neutral ambient temperatures.2. In hydrated cats measurements of body temperature (T(b)) and evaporative heat loss (e.h.l.) show that infusion of 30% saline (1.5 ml./kg) at an ambient temperature of 38 degrees C, lowers e.h.l. by an average of 0.21 W/kg (P < 0.001) and elevates T(b) by 0.43 degrees C (P < 0.01).3. At 25 degrees C alterations in these two parameters were in the same direction, though not statistically different from pre-infusion levels (P > 0.05).4. Infusion of distilled water (15 ml./kg) into dehydrated animals produced significant increases in e.h.l. (+0.35 W/kg, P < 0.001) and reductions in T(b) (-0.45 degrees C, P < 0.001) at 38 degrees C. No significant effects were observed at 25 degrees C.5. Infusion of water into normally hydrated animals at 38 degrees C also significantly increased e.h.l. (+0.13 W/kg, P < 0.05) and insignificantly lowered T(b) (-0.03 degrees C, P > 0.05).6. Local heating of the preoptic hypothalamic area in four animals indicated that hypertonic saline infusion into normally hydrated animals caused a reduction in the slope and displacement to the right of the relationship between hypothalamic temperature and e.h.l.7. Conversely, water infusion into dehydrated animals increased the slope and shifted this relationship to the left.8. These experiments provide evidence for an osmotic interaction in body temperature regulation which acts to alter the responsiveness of the hypothalamus to increasing temperature. This osmotic component may be an important factor in the alterations in thermoregulation seen in dehydrated animals.