Control of Crystal Size Distribution and Polymorphs in the Crystallization of Organic Compounds

Abstract

Many of organic compounds, such as pharmaceuticals and chemicals, are produced as crystals. Controlling the characteristics of these crystal products with good reproducibility is essential for crystallization of organic compounds. There are various characteristics to be controlled, such as grain size and distribution, crystal polymorphism, crystal habit, and purity, but grain size and crystal polymorphism are particularly essential characteristics. In order to control them, the authors have developed several new crystallizers. This chapter highlights some recent crystallizers to produce organic crystals with high quality.