Control of bone remodeling by nervous system. Regulation of bone metabolism by peripheral nervous system

Abstract

Bone is richly innervated with adrenergic and peptidergic nerve terminals, and these play important roles in bone remodeling. Recent study confirmed a functional nerve-osteoblastic interplay by using an in vitro co-culture model comprising mouse osteoblastic cells and neurite-spouting mouse superior cervical ganglia. This indicates that nerve-osteoblastic cell cross-talk can occur for the dynamic regulation of local bone metabolism by peripheral nervous system. This review summarized both in vivo and in vitro evidences implicating peripheral neuron action in bone metabolism.