Abstract
The purpose of this investigation was to determine the aromatizing capacity of luteal and nonluteal tissues throughout the second half of pregnancy and to find out what regulates the aromatizing systems in both the corpora lutea and ovarian nonluteal tissues of the pregnant rat. Luteal and nonluteal tissues obtained between days 12–22 of pregnancy were incubated for 4 h in vitro with testosterone (T) substrate. The net synthesis of 17β-estradiol (E) was masured as an index of aromatase activity. Corpora lutea isolated on all days of pregnancy exhibited a striking capacity to convert T to E. The aromatizing capacity of luteal tissue increased significantly from day 12 through day 15, then declined steadily until the end of pregnancy. The nonluteal tissue synthesized significantly less E than the luteal tissue, with the levels of E produced remaining constant through day 19 and increasing by day 22. Hypophysectomy on day 12 of pregnancy resulted in a complete loss of aromatase activity in nonluteal tissue a...
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