Abstract
Information concerning energy deposition during laser therapy of skin is needed to comprehend and asses the results of clinical procedures in dermatology. The prupose of this study is to show an optical model that predicts infection dose for the skins in different hair density and which can be used to explore whether parameteres of hair on the skin surface, merited the bio optical sudies and phsician during irradiation. A skin optic study by the advanced system analysis program (ASAP) software represents the best way for improving investigation of light propagation into the skin. The ASAP technique of the skin modeling is the process of constructing optical objects, such as a set of skin layers and propagation of a laser beam, whose behavior or properties correspond in some way to a particular real-wold system. The results showed that, hair on the skin surface minimized dose injection of the skin target during the PDT procedure. The differences in penetrating injection dose for layers of skin between low and high hair densities after irradiation, for end epidermis layer at 0.098 mm in the skin region with high and low hair density are 832.1 mW.mm-3 and 853 mW.mm-3 respectively, but for skin without hair is mW.mm-3. Using this resutl, we found that the region of decreased light fluence rate that formed at the epidermis layer significantly reduces the power uptake in deep layers. Moreover, hair density on the skin surface precents light penetration into the deeper region. Therefore, if the hair parameters are ignored, a relatively significant effect of the dose rise occurs in a deeper area resulting great influence in depth of target.
Highlights
In the last decade, advances in bio optics, and skin optics as well as laser technology has enabled the development of a practical model in optical biomedical engineering technique and photodynamic therapy (PDT) applications(Forslind, Engström, Engblom, & Norlén, 1997; San, John, Anderson, & Michael, 1981)
The findings show that the ratio of loss in light delivery from the stratum corneum to the end of epidermis layer is increases with increasing ratio of hair density
Our results indicated that the hair density of the skin surface must be considered in PDT subjects for epidermis diseases
Summary
Advances in bio optics, and skin optics as well as laser technology has enabled the development of a practical model in optical biomedical engineering technique and PDT applications(Forslind, Engström, Engblom, & Norlén, 1997; San, John, Anderson, & Michael, 1981). PDT is one of the most promising areas of medical application, treating malignant and non-malignant disease (Huang, 2006; Moseley et al, 2006). The sufficient light must be delivered to adequately penetrate the epidermis to produce chemical interaction with photosensitizer into a deepest layer of tumor into the skin (Sibata, Colussi, Oleinick, & Kinsella, 2000). This energy must be delivered to the target over the appropriate condition to interact safely and correctly (Bahmer et al, 2008; Kalka, et al, 2000). Formal light fluence rate analyses have largely been undertaken in the medical application and focus on the PDT(Robinson, et al, 1998b; Star, 1997)
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