Abstract
Control and resolution mechanisms of the inflammatory response.
Highlights
Mediators of Inflammation tested hypothesis that apoptotic cells induce the expression of the hepatocyte growth factor (HGF) through activation of the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) signaling in macrophages
The results presented indicate that the HGF/c-Met and COX-2/PGE2 signaling pathways communicate with each other via a positive feedback crosstalk loop, enhancing the synthesis of PGE2 and HGF, that in turn act as anti-inflammatory and antifibrotic molecules during the interaction of apoptotic cells with macrophages
Current and future studies including different pathogenic microorganisms and cell types will allow the identification of key interconnection points of several signaling pathways that may be used as novel targets to control inflammation during infections and noninfection diseases
Summary
Mediators of Inflammation tested hypothesis that apoptotic cells induce the expression of the hepatocyte growth factor (HGF) through activation of the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) signaling in macrophages. Control and Resolution Mechanisms of the Inflammatory Response Baizabal-Aguirre,[1] Carlos Rosales,[2] Constantino López-Macías,[3,4] and Marisa I.
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