Abstract
THE CONCEPT OF NEUROSYPHILIS The present day concept of syphilis of the nervous system is little over one hundred years old. It has been developed by definite stages in which Bayle, Virchow, Heubner, Nissl, Alzheimer, Hoffman, Ehrlich, Noguchi, Moore and others have played successive roles. Owing to the classic accomplishments of these pioneer students of neurosyphilis, one is able to comprehend its syndromes today as the phenomena of a chronic infection reaction in the human nervous system caused by Spirochaeta pallida. Through the changes in the blood and the spinal fluid and the reactions of the meninges, vessels and parenchyma of the brain, the clinical and pathologic aspects of these important disease entities are daily being revealed in increasing completeness. Prior to the publication of the work of Bayle and of the other investigators of the period that his observations initiated, the picture of neurosyphilis was not at all clear.
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