Contributions of transient and sustained reward to memory formation.

Abstract

Reward benefits to memory formation have been robustly linked to dopaminergic activity. Despite the established characterization of dopaminergic mechanisms as operating at multiple timescales, potentially supporting distinct functional outcomes, the temporal dynamics by which reward might modulate memory encoding are just beginning to be investigated. In the present study, we leveraged a mixed block/event experimental design to disentangle transient and sustained reward influences on task engagement and subsequent recognition memory in an adapted monetary-incentive-encoding (MIE) paradigm. Across three behavioral experiments, transient and sustained reward modulation of item and context memory was probed, at both 24-h and ~ 15-min retention intervals, to investigate the importance of overnight consolidation. In general, we observed that transient reward was associated with enhanced item memory encoding, while sustained reward modulated response speed but did not appear to benefit subsequent recognition accuracy. Notably, reward effects on item memory performance and response speed were somewhat inconsistent across the three experiments, with suggestions that RT speeding might also be related to time on task, and we did not observe reward modulation of context memory performance or amplification of reward benefits to memory by overnight consolidation. Taken together, the observed pattern of behavior is consistent with potentially distinct roles for transient and sustained reward in memory encoding and cognitive performance and suggests that further investigation of the temporal dynamics of dopaminergic contributions to memory formation will advance the understanding of motivated memory.