Abstract
AbstractAlzheimer’s disease (AD) and cerebrovascular disease (CVD) are generally considered the most common causes of cognitive impairment and dementia in older persons and are independent but frequently comorbid pathological processes. It is well established that AD is a major contributor to cognitive impairment and dementia, but the effects of CVD are less clear. Not only is there controversy about the magnitude of CVD effects in general, but CVD is also pathologically heterogenous and there also are important questions about how specific manifestations of CVD relate to cognition.KeywordsItem Response TheoryWhite Matter HyperintensitiesClinical Dementia RateCortical Gray MatterTotal Intracranial VolumeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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