Abstract
Objective: validate method of fixation of dressings on excisional cutaneous wounds of mice. Method: preclinical study. Sample made up of animals of the C57BL/6 strain, which had two excision wounds made in the dorsal region. Different methods and products, widely accepted in clinical practice, for fixing dressings in the animal model were evaluated. The evaluated outcomes were the length of stay of the dressing and the occurrence of adverse events. Results: crepe bandage, microporous tape and self adhesive bandage had a shorter residence time when compared to polyurethane film. This, in turn, varied the time when comparing different marks (E, F, G and H) and number of turns around the animal’s body. With 1 lap, the time varied from <24 to 36 hours. With 2 laps, the marks E and G remained 48 and 96 hours, respectively, and F and H time <24 hours. G-brand film, cut to size 3 cm x 15 cm, giving the mouse body 2 turns, kept the dressing for 96 hours. The skin remained intact, with no adverse event. Conclusion: a dressing fixation model for wounds in mice was created with a product available in Brazil and compatible with the animal’s body structure.
Highlights
Basic research can contribute to solving problems inherent to nursing care[1] when the research results allow its translation into clinical practice[2]
It is noteworthy that the animal model allows the evaluation of biological phenomena, which can be compared to humans3,with an emphasis on translational research
There is variability in experimental studies that address the healing of skin wounds, but, contradictorily, these studies are conducted by other professional categories[4,5]
Summary
Basic research can contribute to solving problems inherent to nursing care[1] when the research results allow its translation into clinical practice[2]. Animal experimentation allows the understanding of knowledge gaps related to physiological and pathological processes, which can impact clinical nursing practice. There is variability in experimental studies that address the healing of skin wounds, but, contradictorily, these studies are conducted by other professional categories[4,5]. Such an issue may limit the implementation of nursing interventions in the treatment of wounds in the context of in vivo research
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